Founded in 1960 by the American writer and sociologist, Eric Estorick, who dealt primarily in Russian Constructivism and Italian Futurism, Grosvenor Gallery now specializes in Indian and Pakistani Modernist artists of the period 1947 to the present.

Since 2000, the current directors and owners, Conor Macklin and Charles Moore, have focused on the Indian and Pakistani Modernists, primarily F.N. Souza (1924-2002) whose estate is represented by the gallery, M.F. Husain (1913-2011), and S.H. Raza (1922-2016) with whom they have extensively collaborated and exhibited, as well Pakistani artists Syed Sadequain (1930-1987) and A.R. Chughtai (1897-1975). They also exhibit one of the few living artists of this generation Krishen Khanna (b.1925), and have a Contemporary program, exhibiting young artists from South Asia and some more established such as Rasheed Araeen (b.1935).

The gallery works closely with all the major collectors of the region as well as the curators and museums with an interest in this area, including recent shows at Tate Britain All Too Human, and The Progressive Revolution at the Asia Society in New York.